The master regulator of innate T cell metabolism
Mucosal associated invariant T (MAIT) cells are a type of innate-like T cells that are enriched in adipose, gut, and liver tissue and that recognize bacterial metabolites. Upon activation, they proliferate and produce cytokines to promote host defense. Kedia-Mehta et al. showed that MAIT proliferation depended on MYC-associated pathways involving amino acid transport and glycolysis. Furthermore, MAIT cells from patients with obesity showed disrupted function and engagement of these pathways. These findings demonstrate that the canonical metabolic pathways found in conventional T cells are active in MAIT cells and may be relevant to the development of MAIT cell-based therapies and the study of obesity. —AEB
Abstract
Mucosal-associated invariant T (MAIT) cells are an abundant population of innate T cells that recognize bacterial ligands and play a key role in host protection against bacterial and viral pathogens. Upon activation, MAIT cells undergo proliferative expansion and increase their production of effector molecules such as cytokines. In this study, we found that both mRNA and protein abundance of the key metabolism regulator and transcription factor MYC was increased in stimulated MAIT cells. Using quantitative mass spectrometry, we identified the activation of two MYC-controlled metabolic pathways, amino acid transport and glycolysis, both of which were necessary for MAIT cell proliferation. Last, we showed that MAIT cells isolated from people with obesity showed decreased MYC mRNA abundance upon activation, which was associated with defective MAIT cell proliferation and functional responses. Collectively, our data uncover the importance of MYC-regulated metabolism for MAIT cell proliferation and provide additional insight into the molecular basis for the functional defects of MAIT cells in obesity.
Sources from: SCIENCE.ORG
SVE NEWS is the leader in world news liberal sharing.
(Comments on this news are welcome)
2022 CWMALLS: Standard, Sharing,Ecology, Value;
2022 CWMALLS COMMODITY: Patent, Technology, Art, Intelligence;
2022 CWMALLS NEW SPECIES: Keen, Aggressive, Personality, Value;
2022 MWE FUND: Charity, Public Welfare, Responsibility
2022 CWS is with the world and Mars!
Tips: In order to explore more planet species diversity and ecosystem of Mars and earth’s biosphere of cohesion, from now on in the chosen experts and scholars of Mars and planets, especially the astrophysicist, astrobiologists, astrochemists, and so on all over the world’s elite, contribute to the existence and development of simulation of Mars landing. Thank you very much! CWS (Mars) Asia-Pacific Preparatory Committee 0086-57189877088/89877099, E-mail: mars@cws-mars.com, Twitter: CWS, October 3, 2021